16th February 2021Produced by:
The natural ingredients in Intenza’s Prostate Power Flow product, described below, have a history of traditional herbal medicine use and have demonstrated their safety and efficacy in human clinical trials. A brief summary of some of the evidence available for each ingredient is described below.
The key ingredients with the highest level of evidence from human clinical trials are:
Saw Palmetto has been used to ease symptoms related to Benign Prostate Hypertrophy for more than 100 years. Multiple modern human clinical trials have demonstrated Saw Palmetto improving lower urinary tract symptoms due to prostate irritation, inflammation, or hypertrophy. The clinical evidence is stronger when Saw Palmetto is included in multiple ingredient therapy and has been traditionally combined with Nettle root extract.
Nettle root extract has been demonstrated to have an effect on improving lower urinary tract symptoms in a number of human clinical trials both when used on its own or in combination with Saw Palmetto.
Graminex Flower pollen extract
Graminex® G63® Flower Pollen Extract™ is a combination of two standardised solvent free pollen extracts, one a water-soluble fraction and the other an oil soluble fraction. This unique combination has been shown to be beneficial for male reproductive health in multiple human trials. Graminex enhances prostate health and supports healthy prostate function and supports male sexual health and healthy libido. A recent review of clinical trials showed that Graminex flower pollen extract used to treat prostatitis (the swelling and inflammation of the prostate gland) was found to have a significant improvement in quality of life, and a reduction in the National Institutes of Health-Chronic Prostatitis Symptom Index (NIH-CPSI) score.
Zinc and Selenium
The above key herbal ingredients are combined with the nutritional supplements’ lycopene, zinc and selenium which have demonstrated benefits for supporting key cellular biochemical pathways that support testosterone metabolism and hormone balance.
Multiple modern human clinical trials have demonstrated Saw Palmetto improving lower urinary tract symptoms due to prostate irritation, inflammation or hypertrophy. These clinical trials have been reviewed and have been subjected to Meta-Analysis. In 2002 a Cochrane review of 21 RCT’s involving 3139 men concluded that saw palmetto improves lower urinary tract symptoms including peak urine flow and night time urinary frequency to a similar degree as the drug finasteride and with less side effects (Wilt et al., 2002). The clinical evidence is stronger when Saw Palmetto is included in multiple ingredient therapy and has been traditionally combined with Nettle root extract.
Nettle root extract has been demonstrated to have an effect on improving lower urinary tract symptoms in a number of human clinical trials both when used on it’s own or in combination with Saw Palmetto. This effect was seen to be similar to that of conventional drug therapy (Azimi et al., 2012).
Graminex Flower Pollen Extract
A recent review of flower pollen extracts used for chronic prostatitis found that 6 clinical, non-controlled studies including 206 patients, and 4 RCTs including 384 patients were conducted. The mean response rate in non-controlled studies was 83.6% (62.2%-96.0%). The meta-analysis revealed that flower pollen extract could significantly improve patients’ quality of life [OR 0.52 (0.34-.0.81); p = 0.02] and reduce the symptoms score of prostatitis. No significant adverse events were reported (Cai et al., 2017).
Lycopene is a natural carotenoid extract from tomato that has shown anti-inflammatory and antioxidant effects that may support prostate health.
Zinc Amino Acid Chelate
Zinc Amino Acid Chelate is a bioavailable form of the mineral zinc. Zinc is an essential mineral involved in many biochemical reactions in the body. It is most known for it’s role in supporting a proper functioning immune system but is also required for optimal prostate function and testosterone production and metabolism. The prostate has the highest concentration of zinc of all body tissues and prostate zinc levels have been found to fall as we age. Low levels of testosterone have been found in cases of zinc deficiency (Baltaci et al., 2019).
A vital micronutrient that many people in NZ and Australia are deficient in. Selenium is required for many biochemical reactions including testosterone metabolism and thyroid hormone production. It therefore has an impact on fertility and energy levels (Rayman, 2012). Multiple clinical studies have illustrated selenium having a key role in male prostate health, fertility and sexual wellbeing.
Azimi, H., Khakshur, A.-A., Aghdasi, I., Fallah-Tafti, M., & Abdollahi, M. (2012). A review of animal and human studies for management of benign prostatic hyperplasia with natural products: perspective of new pharmacological agents. Inflammation & Allergy Drug Targets, 11(3), 207–221. https://doi.org/10.2174/187152812800392715
Baltaci, A. K., Mogulkoc, R., & Baltaci, S. B. (2019). Review: The role of zinc in the endocrine system. Pakistan Journal of Pharmaceutical Sciences, 32(1), 231–239.
Cai, T., Verze, P., La Rocca, R., Anceschi, U., De Nunzio, C., & Mirone, V. (2017). The role of flower pollen extract in managing patients affected by chronic prostatitis/chronic pelvic pain syndrome: a comprehensive analysis of all published clinical trials. BMC Urology, 17(1), 32. https://doi.org/10.1186/s12894-017-0223-5
Rayman, M. P. (2012). Selenium and human health. Lancet (London, England), 379(9822), 1256–1268. https://doi.org/10.1016/S0140-6736(11)61452-9
Wilt, T., Ishani, A., & Mac Donald, R. (2002). Serenoa repens for benign prostatic hyperplasia. The Cochrane Database of Systematic Reviews, 3, CD001423. https://doi.org/10.1002/14651858.CD001423